Unlike conventional techniques, PIMS® takes account of macromolecular interactions in a natural cellular environment. This label-free technology is based on dynamic molecular resonance of proteins and macromolécules.
PIMS® is able to study protein-protein and protein-solvent interactions in multicomponent solutions. It provides a real-time dynamic fingerprint of total physiological macromolecular assemblies in a tissue in the presence or absence of exogenous molecules (drug or drug candidate, peptide or protein). PIMS® can quickly identify the response of a tissue or cell when an exogenous molecule is administrated. It therefore reflects patients’ molecular capacity to respond to the drug’s effect and allows different subpopulations within a group to be identified in response to specific treatment.
PIMS® analyses the differential molecular oscillation (DMO) and relative dynamic diffraction (RDD) of a tissue in the presence of the drug candidate being tested.
Differential Molecular Oscillation (DMO) is the difference in molecular resonance as a function of time and surrounding environment in the presence of an exogenous molecule compared to the blank.
Relative Dynamic Diffraction (RDD) depends on surrounding water molecules in the presence of an exogenous molecule compared to a blank.
This technique is used in the early stages of drug development, as well as in patient stratification.
Depending on how patients respond to different treatments on the market, PIMS® can safely and accurately determine the best therapy for them.
PIMS® offers significant opportunities in the field of personalised medicine and biomarkers.