Breakthrough protein technologies

for each phase of the drug development process

Inoviem is the only bioanalytical CRO to use label-free technologies under physiological conditions and in human tissue. NPOT® and PIMS® have proved to bring significant advantages to target identification and in confirming target engagement with compounds.

Unlocking drug mechanism of action in native biological contexts

NPOT® is a biophysical platform that maps how drugs interact with proteins in their native, unaltered state. By analysing tissues, cell lines, or patient biopsies directly, NPOT® identifies drug targetsinteraction networks, and biomarkers; without disrupting the natural biological environment. Compatible with small molecules, antibodies, peptides, and large compounds, NPOT® accelerates drug discovery by revealing how therapies truly work in disease contexts.

Physiological Intermolecular Modulation Spectroscopy

PIMS® is a patented, label-free biophysical and analytical technology designed to study molecular interactions and predict therapeutic responses in biomedical research.

Ligand Induced Phase Shift: A label-free tool for drug-target engagement analysis

LIPS is an innovative, label-free method designed to measure drug-target interactions with high accuracy in native environments, including cultured cells and patient tissues. By leveraging the natural charge and behavioural changes in proteins upon drug binding, LIPS separates proteins into aggregated (pellet) and soluble (supernatant) phases using pH-variable plates and hydrophobic conditions. This allows precise quantification of drug-induced effects without artificial markers.

Proteomic profiling for Biomarkers Discovery in human Whole Blood and complex human matrixes (Serum, Plasma, Sputum, Balf, Urine)

Inoviem has developed a sensitive and accurate proteomic methodology for the proteomic profiling of human individuals in the context of translational evaluation of biomarkers and clinical development of new drug candidates. The methodology works with both human frozen whole blood and any other matrixes including plasma/sera, urine, sputum etc.

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